Donepezil is emerging as a potential therapeutic treatment in improving endothelial barrier function to prevent and treat coronary artery disease in Diabetes Mellitus.

Abstract Current treatments have shown limited success in reversing DM induced vascular endothelial barrier dysfunction. Vascular endothelium forms the inner most lining of blood vessels, regulates variety biological processes such as angiogenesis, wound healing and host defense mechanisms. During inflammatory conditions, diabetes mellitus myocardial infarction cell-cell junctions start to disrupt because internalization junctional proteins, (VE) cadherin. This leads formation minute inter-endothelial gaps, infiltration protein-rich fluid immune cells interstitial space. If remains unchecked, persistent buildup edema underlying sets stage for serious life-threatening complications. Therefore, we hypothesized that donepezil prevents high glucose-induced dysfunction by preventing destabilization proteins. We investigated potential protective role Donepezil glucose increase human coronary artery (HCAE) permeability process. Wound assay was performed employing electric signals both monitor process monolayer. To investigate signaling mechanism involved protection offered Donepezil, found prevented loss VE-cadherin junctions, abrogated stress fiber cell exposed high-glucose solution. In conclusion, our study shows maintained function improved glucose. Chicago State University CTRE grant Professor Nadeem Fazal, MD, PhD